DIVISION OF REGENERATIVE HEALTH
NIH GRANTS
Fibroplate, Inc has developed a biological product that can
(a) Mobilize the patient’s own stem cells to heal deep wounds
(b) Stop internal and external bleeding related to low platelet count
(c) Suppress pro-inflammatory cytokines (cell signals to other cells)
to accelerate healing
1. Development of medical Countermeasures to Enhance Platelet Regeneration
and Survival Following Radiation Exposure from a Radiological/Nuclear Incident”:
NIH Contract No. HHSN272201400034C. The award period is from Sep 1, 2014
to Aug 31, 2016. Now completed with excellent results showing improvement in
animal survival after a lethal dose of irradiation from 5% to 60%. See Publication:
“Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenic Related
Bleeding” in Radiat Res 2020 August 01; 194(2): 162-172.
2. “A multivalent, easy-to-use product to mitigate and treat radiation exposure”
(Phase 1) NIH Grant no. 1R43Al142964-01. Grant period 01/01/2019 to
06/20/2019. Now completed with excellent resulting showing the role of stem
cells in skin total-thickness recovery after a severe dose of local irradiation.
Publication: “Radioprotective Efficacy of Fibrinogen-coated Albumin Spheres
Against Radiation-induced Skin Damage” in Radiat Res 2019, Sep 13.
3. “A multivalent, easy-to-use product to mitigate and treat radiation exposure”
(Phase 2) NIH Grant no. 1R44Al142964-02. Grant period 05/01/2021 to
04/30/2022, extended to 04/30/2023. Now completed with excellent results
proving Fibroplate product can promote neo-vascularization after radiation
damage. Publications pending.
4. “Fibrinogen coated albumin spheres to accelerate bone healing in older adults”
NIH Grant No. 1R43AG072919-01A1. Grant period is 09/30/2021 to 05/31/2022
extended to 05/31/2023. Now completed with excellent results showing the effect
of stem cells at the healing site. Results are used to support a Phase II grant
application to NIH which has been submitted April 2025. Publication: Fibrinogen-
coated albumin spheres to accelerate bone healing in older rats” presented at the
Orthopedic Research Society, 2024 Annual Meeting in Long Beach, California,
February 2-6.