DIVISION OF REGENERATIVE HEALTH PROJECTS
· Accelerated Healing of Surgical Wounds
Fibroplate’s premier medical product called Fibrinoplate-S (FPS) has at least three modalities of healing: (1) mobilize the patient’s stem cells toward a wound to accelerate healing, (2) stop bleeding by augmenting the patient’s platelet function without forming random clots, (3) suppress pro-inflammatory cytokines (cell-to-cell signals during inflammatory events). The Company received an NIH grant to evaluate FPS in breast cancer patients who need surgery and radiation therapy.
Improved Survival after Total-body Irradiation
Many patients need total-body irradiation to completely remove their cancer cells. However, such treatments are often harmful. Work completed in collaboration with Duke University (Supported by NIH) showed that survival of animals after such irradiation can drop to 5%. However, after treatment with Fibrinoplate-S, the survival rate improves to 60%. This product should be helpful for radiation therapy patients or even in the event of a nuclear accident.
· Multi-tissue Recovery from Radiation Trauma
Radiation therapy is aimed at killing cancer cells with the minimal harm to the patient. Even so, many patients cannot tolerate it and will develop skin ulcerations. The Company Product called Fibrinoplate-S is able to accelerate healing by mobilizing stem cells to the wound and by repairing damaged blood vessels beneath the wound so that multiple issues around the wound can receive nutrients and recover quickly. Work was funded by two NIH grants.
· Bone Fracture Healing in Old Patients
Older people tend to have weaker bones. Weaker bones can lead to falls and injuries. The Company Product called Fibrinoplate-S is able to increase the mineral content of the healing area and accelerate healing due to the abundance of stem cells mobilized from the bone marrow. Work was funded by an NIH grant.